Grants

Ongoing

2008 -2010 NERC (£22 590 PI, part of larger grant with K Chipman, Bham). Distinguishing toxic from adaptive responses in fish using omics - a key for integration of toxicogenomics into environmental risk assessment.

2008 -2009 NERC (£82 224 PI). Knowledge transfer - Impacts of inbreeding on the responses to pharmaceuticals and fitness consequences in fish - a molecular approach.

2008 Royal Society (£15 000 co-I with E Santos). Molecular pathways determining reproductive dominance in male zebrafish.

2008 -2011 EPSRC/DEFRA-LINK (£628 000 co-I, with T Galloway part of £3.2M consortium grant). The ecotoxicological of metal oxide nanoparticles

2008 Astrazeneca (£12 314 PI). Research Contract for fish gonadal histopathology.

2008 -2009 The Environment Agency. Impacts of EDCs in the River Itchen (£31 500 PI).

2008 -2011 The Environment Agency, and Peninsular College for Medicine and Dentistry (£20 000 PI). Environmental Impacts of metal oxide nanoparticles.

2008 -2009 Severn Trent Water. (£71 500 - PI). Impacts of EDCs in WWTW effluents.

2008 -2009 NERC NE/G011133/1 (£49 913 co-I with R vanAerle). Application of transcriptomics in advancing our understanding of chemical effects and potential impacts in fish – A practical demonstration

2008 –2009 DEFRA (£40 000-PI) Population level consequences of endocrine disruption in wild roach- project extension.

2008 –2009 Environment Agency (£43 000-PI) Funding for projects on micropollutants

2009 -2010 The Environment Agency. (£36 010 - PI). Effects of WWTW remediation on EDCs impacts in the River Itchen

2009 –2010 NERC – FENAC facility award. Assessment of the utility of primary trout hepatocyte culture in screening nanoparticles for potential toxic effects

2008 -2010 NERC (NF/F001320/1, £165 068 co-I A. Cossins, S. Paterson, U of Liverpool). Data mining pipelines for unbiased interpretation of large scale microarray datasets in environmental research using non-model species.

2008 -2010 NERC (£164 642 co-I T Ebbles, Imperial, et al,). Data mining and integration strategies for ecotoxicogenomics

2008 -2010 NERC (£22 590 PI , part of grant larger with K Chipman, Bham). Distinguishing toxic from adaptive responses in fish using omics - a key for integration of toxicogenomics into environmental risk assessment.

2008 -2009 NERC (£65 779 PI). Knowledge transfer - Impacts of inbreeding on the responses to pharmaceuticals and fitness consequences in fish - a molecular approach.

2007 –2010 NERC (£128 000 co-I with J Lead, Birmingham, administered at Bham). Engineered nanoparticles in the natural aquatic environment (nanonet) NE/E002889/1

2007 –2010 NERC (£13 500 PI with B Johnston). Understanding the environmental behaviour and biological impacts of manufactured nanoparticles in natural aquatic systems. OSS/333/1206.NERC- ICP Facility

2007-2009 Environment Agency (£8 000, PI). Development and application of DNA microsatellite markers in roach.

2007 –2010 NERC (£400 000 with J Lead, Birmingham £205 000 to Exeter, PI). Understanding the environmental behaviour and biological impacts of manufactured nanoparticles in natural aquatic systems.

2007 Environment Agency (£8 000, PI) Application of DNA microsatellites to address population level impacts of intersex in wild roach

2007 –2010 NERC (£560 000 with L Hill, Sussex £281 927 to Exeter, PI). The significance of anti-androgens in disrupting sexual function in wild fish in UK Rivers

2007 –2010 NERC NE/E008429/1 (£150 000 with V Stone, Napier University, co- I). Assessing Human Exposure, Uptake and Toxicity of Nanoparticles from Contaminated Environments

2007 NERC (£62 400 with B Johnston). Further investigations of the environmental behaviour and biological impacts of manufactured nanoparticles in natural aquatic systems. OSS/348/0507.NERC- ICP Facility

2007-2009 Spanish Government ( £80k co-I with Dr Francisco Baella). The roles of GDF-9 and BMP-15 in the regulation of early oocyte development in fish and their relation to fertility. Studying potential applications for the control of fish reproduction.

2007-2008 Syngenta (£5k PI). Zebrafish embryo development work- lab space grant.

2006-2007 Environment Agency (£20 000, PI). Evidence for Oestrogenic impacts in the River Itchen.

2006-2009 NERC (£400 000 with M. Viant, Birmingham, £212 000 to Exeter, PI). Diagnosing toxicant specific disruption of sexual development in wild fish using metabolomics.

2006-2009 NERC (£390 000 with J Lead, Birmingham £198 000 to Exeter, PI). Understanding the environmental behaviour and biological impacts of manufactured nanoparticles in natural aquatic systems. .

2005-2010 Hants and IOW Wildlife Trust (£15 000, co-investigator with J Stevens). Microsatellites for otters.

2002-2005 The Wellcome Trust. (£48 047, PI). Effects of the pesticide cypemethrin on gametogenesis and gamete quality in the zebrafish, Danio rerio.

2005-2009 DEFRA. (£325 000, PI). UK-Japan Supervisor, Research and Travel Initiative for research into endocrine disruption.

2005-2008 DEFRA (£518 400 co-PI with J.Sumpter, Brunel University, £195k directly to Exeter, part of £1.5M consortium grant) Population level consequences of endocrine disruption in wild roach.

2005-2008 NERC Genomics Thematic. (£188 174, co-investigator with K. Chipman, Birmingham). International Consortium on Fish Genomics.

2005-2008 NERC Genomics (£55 000, co-investigator with K. Chipman, Birmingham). Knowledge Transfer Grant.

2005 Environment Agency (£5 000, PI). An analysis of further effluents from sewage treatment works for estrogenic and anti-androgenic effects.

2005-2010 DEFRA. (£75 500, PI). UK Supervisor for UK-Japan Initiative for research into endocrine disruption.

2005-2007 Environment Agency /Astrazeneca-Industry (£85 000, PI) Molecular markers for signalling health effects of exposure to complex chemical mixtures contained in treated sewage effluents in the fathead minnow (Pimephales promelas).

2005 NERC Travel Grant (£5000, PI). UK-Japan Travel Grant 2005 WRc-NSF plc. Endocrine activities in treated effluents (£12 480, PI).

2005-2008 NERC Genomics Thematic (£285 000, PI - part or £1.5M consortium grant co-ordinated by K. Chipman, University of Birmingham). Integrated transcriptomics, proteomic, and metabolomic approaches to identify and define the basis of individual and population susceptibility and adaptation to environmental pollutants in fish.

Previous grants

2005 Essex and Suffolk Water-Industry. (£9 000, PI). Oestrogenic activity in recycled water

2004-2007 AstraZeneca - Industry. (£9 000, PI). Sexual disruption in dippers (Cinclus cinclus) and bullheads (Cottus gobio) in the Tamar Catchment.

2004 AstraZeneca- Industry. (£8 000, PI). Development of histological markers for sexual disruption

2004-2006 Environment Agency /Astrazeneca (£300 000, PI, £228 000 directly to Exeter). Impacts of treated sewage effluents on reproductive function in the fathead minnow (Pimephales promelas).

2004-2007 Environment Agency (£77 000, PI). Ontogeny of sex determination and development, and the Impacts of long-term exposure to steroid oestrogen on sex cell development, in the roach (Rutilus rutilus).

2004-2007 Environment Agency (£36 000, PI). Funding to establish a National breeding and hatchery unit for fathead minnow (Pimephales promelas).

2004-2005 Environment Agency (£16 000, PI). Funding to support employment of a research technician to support work on the development of a reproductive performance test in fish for assessing the effects of endocrine disrupting chemicals in fish.

2003-2007 Environment Agency (£15 000, PI). Application of microsatellite markers for reproductive and population biology studies in fish.

2003-2006 Natural Environment Research Council - Environmental Genomics Thematic with Liverpool University (£746 873 – PI, £315 000 directly to Exeter). Identification of the mechanisms of disruption of sexual differentiation in fish exposed to endocrine disrupting chemicals and their mixtures - A transcriptomic approach.

2003-2005 Environment Agency (£55 000, PI). Developing tests or endocrine disrupting chemicals for use in risk assessment – contract extension.

2003-2004 Environment Agency /DEFRA ( £13,750, PI).An investigation into fish life stage sensitivities to oestrogenic chemicals in treated sewage effluent (contract extension).

2003-2006 DEFRA (£70 000, PI with Dr Katsiadaki, CEFAS, administered at Exeter). Addressing the biological relevance of anti-androgenic xenobiotics.

2002-2005 European Union- (£160 000,PI) Comparative Research on Endocrine Disrupters

2004 European Union (£8k), Environment Agency (£5k), CEFIC (£1.5k), Astrazeneca (£1k), Molecular Light Technology (£1k), Biosense (£1k), DEFRA (£9.5k) Total -£27 000, PI). Funding to support an International Meeting on Endocrine Disruption in Wildlife at Exeter.

2003 Environment Agency (£15 000,PI ). National R and D Programme on sexual disruption in wild fish. Oestrogenic activity in effluents from sewage treatment works.

2003 Water Research Council-NSF 3 contracts (£24 000, PI). Hormone activity (anti-androgenic and anti-oestrogenic) in effluents from sewage treatment works throughout England.

2003 Environment Agency (£8 100, PI). Anti-androgenic effects of effluents from sewage treatment works in fish.

2003 NERC –Funding for Royal Society Exhibition (£3 500, co-PI)

2003-2004 Environment Agency (£7 994, PI). National R and D Programme on sexual disruption in wild fish Vitellogenin concentrations in intersex fish ( 2 contracts).

2003 Environment Agency (£4000, PI). Histological assessment of the effects of the pesticide linuron in fish

2002-2004 European Union. Marie Curie Fellowship. (£70 000, PI). Identifying genetic biomarkers for sexual disruption in zebrafish (Danio rerio).

2002-2004 Environment Agency/ELFF. (£4 400, co-PI). Reproductive biology of the millars thumb (Cottus gobio) in the River Axe.

2002 Environment Agency/UKWIR (£6 500, PI). Windows of sensitivity for sexual disruption in roach exposed to oestrogenic chemicals in treated sewage effluent.

2002-2004 European Union Marie Curie Fellowship. (£70 000, PI). Molecular characterisation of signalling pathways for sexual disruption.

2002-2003 University of Exeter. (£15 000, PI). Widening Participation Fund – Teaching related grant.

2002 Environment Agency (£15 749, PI). National R and D Programme on Sexual Disruption in Wild Fish. Vitellogenin concentrations in fish in low, medium and high-risk river catchments.

2002 Avecia, DEFRA and Environment Agency (£7 750, PI). Contracts to screen for oestrogenic activity of pesticides and other chemicals.

2001 University of Exeter (£35 000, PI). Funding to support establishing a new Ecotoxicology facility.

2001-2004 Environment Agency/AstraZeneca (£386 000, PI - £170 000 directly to Exeter). Developing tests or endocrine disrupting chemicals for use in risk assessment

2001-2002 University of Exeter.(£18 000, PI). Widening Participation Fund – Teaching related grant.

2001-2004 Environment Agency/UKWIR (£132 000, PI - £72 500 directly to Exeter). An investigation into fish life stage sensitivities to oestrogenic chemicals in treated sewage effluent.

2001 Department of the Environment, Transport and the Regions. (£16 800, PI). Funding to construct a mesocosm.

2001 EPSRC- Doctoral Training Award. (£5 166, PI) 2001-2004 Molecular Light Technology – Industry (£11 750, PI). Quantifying the dynamics of vitellogenin and zona pellucida protein mRNA transcript responses in fish exposed to steroid oestrogens.

2001-2004 Department of the Environment Transport and the Regions (£77 000, co-investigator with J. Sumpter, Brunel University – administered at Brunel). A search for evidence of endocrine disruption in reproduction in top predator fish.

2001-2005 Biology and Biotechnology Research Council. (£267 000, PI) Fish and Chips: Identifying and quantifying xenobiotic induced alterations in gene expression in the brain and gonad.

2001-2004 Engineering and Physical Sciences Research Council (£264 000, PI- £132 00 to Exeter). Sexual Chemistry: Identifying the causative agents of endocrine disruption in fish in UK rivers using HPLC- MS- NMR. With the University of Sussex, Imperial College and Brunel University.

2000 University of Exeter (£50 000, PI). Funding to support Personal Chair in Environmental and Molecular Fish Biology.

1999-2001 Natural Environment Research Council (£186 145, co-PI). Reproductive capabilities of wild intersex fish.

1999-2000 The Environment Agency- Various Contracts (£71 791, PI). Oestrogenic effects of treated sewage effluent in fish.

1999 'Biosense"- Industry (£10, 000, PI). Development of Immunoassays for vitellogenin. 1990-1993- Agriculture, Fisheries and Food Research Council (£16 050, PI). Isolation and characterisation of the vitellogenin receptor in the rainbow trout, Oncorhynchus mykiss.

1998-2002 Biotechnology and Biological Sciences Research Council (£143 859, PI). Molecular characterisation and developmental expression of enzymes mediating yolk processing.

1998-2000 CEFIC - Industry (£112, 000, co-investigator with J.Sumpter, Brunel University). An ecological study to assess bisphenol-A as an environmental oestrogen.

1998-2001 The Department of the Environment, Transport and the Regions (£58 800, PI). Impacts of oestrogenic chemicals on reproductive development in the gudgeon (Gobio gobio) in British rivers.

1998 The Department of the Environment, Transport and the Regions (£80 000, co-investigator with J.Sumpter, Brunel University). Funds to support the building of a fish-breeding unit.

1995-1998 National Rivers Authority. (£6 000, PI).The molecular basis of tumorigenesis in fish.

1995-1998 Biotechnology and Biological Sciences Research Council (£127 892, PI). Molecular characterisation of the vitellogenin receptor and the dynamics of it's expression. 1995-1999 Essex and Suffolk Water (£23 278, PI). Assessing oestrogenic activity in treated effluent.

1995-2000 Natural Environmental Research Council. (£250 000, co-investigator with J.Sumpter, Brunel University). Effects of oestrogenic chemicals on reproductive function in wild fish populations.

1996-1999 The Wellcome Trust (£68 400, PI). Effects of exposure to oestrogenic xenobiotics during early development on the expression of genes controlling sexual development.

1996-1999 The Environment Agency (£84 000, PI). Effects of endocrine disrupting chemicals on the physiology of fish.

1996-2000 The Portuguese Government (£105 000, PI). Mechanisms controlling oocyte growth and recruitment in fish.

1997-1999 Endocrine Modulating Steering Group –Industry (£14 000, PI) testing systems for endocrine disrupting chemicals.

1993-1996- Brunel University Initiative and Enterprise Fund (£6 000, PI). The molecular basis of environmentally induced tumours in fish.

1993-1997 European Community. (£120 000, co-investigator with J.Sumpter, Brunel University). The genetic basis of egg quality.

Ecotoxicology and Aquatic Biology Research Group

Grants

Ongoing

Previous grants