Representative original research papers

A full list of publications is available here

Santos EM, Workman VL, Paull GC, Filby AL, Van Look KJW, Kille P, Tyler CR: Molecular basis of gender and reproductive status in breeding zebrafish. Physiological Genomics 2007, In Press.

Filby, A.L., Thorpe, K.L. and Tyler, C.R. (2006). Multiple molecular effect pathways for an environmental oestrogen in fish. J. Molecular Endocrinology 37: 121-134

Gibson, R., Smith, M.D., Spary, C., Tyler, C.R., Hill, E.M. (2005). Mixtures of oestrogenic contaminants in bile in fish exposed to wastewater treatment works effluents. Environmental Science and Technology 39(8) 2461- 2471

Liney, K.E., Jobling, S. Shears, J., Simpson.P.,Tyler, C.R. (2005) Assessing the sensitivity of different life stages for sexual disruption in roach (Rutilus rutilus) exposed to effluents from wastewater treatment works Environmental Health Perspectives. 113 (10): 1299-1307.

Filby, A.L., and. Tyler, C.R. (2005). Molecular characterization of estrogen receptors 1, 2a and 2b and their tissue and ontogenic expression profiles in fathead minnow (Pimephales promelas). Biology of Reproduction 73:648-662

Nash, J.P., Kime, D.E., van der ven, L.T.M., Wester, P.W., Brion, F., Maack, G.,Stahlschmidt-Allner, P., Tyler C.R. (2004). Long-term exposure to environmental concentrations of the pharmaceutical ethinyloestradiol cause reproductive failure in fish. Environmental Health Perspectives 112:1725-1733.

Thorpe, K., Hetheridge, M.J., Hutchinson, T.H., Scholze, M., Sumpter, J.P., and Tyler, C.R. (2003). Relative potencies and combination effects of steroidal oestrogens in fish. Environmental Science and Technology. 37:1142-1149.

Jobling, S., Coey, S., Whitmore, J. Beresford, N., Nolan, M., Brighty, G., Sumpter, J.P. and Tyler, C.R. (2002) Altered sexual maturation and gamete production in wild roach (Rutilus rutilus: Cyprinidae) exposed to treated sewage effluent in UK rivers Biology of Reproduction. 66(2):272-281.

Thorpe, K., Hetheridge, M., Hutchinson, T.H., Scholze, M., Sumpter, J.P. and Tyler, C.R. (2001). Assessing the interactive effects of binary mixtures of environmental oestrogens in rainbow trout (Oncorhynchus mykiss) using vitellogenin induction Environmental Science and Technology. 35:2476-2481.

Rodgers-Gray, T. P., Jobling, S., Morris, S., Kelly, C., Kirby, S., Jambakhsh, A., Harries, J.E., Waldock, M., Sumpter, J.P. and Tyler C.R. (2000). Long-term temporal changes in the oestrogenic composition of treated sewage effluent and its biological effects in fish. Environmental Science and Technology. 34:1521-1528

Harries, J.E., Runnalls, T.,Harris, C., Hill, E., Sumpter, J.P. and Tyler, C.R.(2000). Development of a reproduction performance test for endocrine-disrupting chemicals in the fathead minnow (Pimephales promelas). Environmental Science and Technology 34: 3003-3011. 1528.

Tyler, C.R., van Aerle, R., Hutchinson, T., Maddix, S, and Trip, H. (1999). An in vivo testing system for endocrine disrupters in fish early life stages using induction of vitellogenin. Environmental Toxicology and Chemistry 18 (2): 337-347.

Jobling, S., Nolan, M., Tyler, C.R., Brighty, G., and Sumpter, J.P. (1998). Widespread sexual disruption in wild fish. Environmental Science and Technology 32: 2498-2506

Prat, F., Sumpter, J.P. and Tyler, C.R. (1996). Validation of radioimmunoassays for two salmon gonadotropins (gonadotropins I and II) and their plasma concentrations throughout the reproductive cycle in male and female rainbow trout, Oncorhynchus mykiss. Biology of Reproduction 54:1375 -1382.

Tyler, C.R., van der Eerden, Sumpter, J.P., Jobling, S. and Panter, G. (1996). Measurement of vitellogenin, a biomarker for exposure to oestrogen, in a wide variety of cyprinids. Journal of Comparative Physiology 166:418-426

Purdom, C.E., Hardiman, P.A., Bye, V., Eno, N.C., Tyler, C.R. and Sumpter, J.P. (1994). Oestrogenic effects of effluent from sewage treatment works. Chemistry and Ecology. 8:275-285

Ecotoxicology and Aquatic Biology Research Group

Representative original research papers